Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsAnalysis of CD45RA-depleted haploidentical mixed lymphocytes culture revealed insufficient suppression of alloresponses in the CD4+ compartment and identified CD276 as a marker for alloreactive memory Th1 T cells.
[Bone Marrow Transplantation]
6445212 MCZDKC6N items 1 apa 0 default asc 1 162095 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-c6129d2d9149cfe0b59fa07aba4f925b%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22MCZDKC6N%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hashimoto%20et%20al.%22%2C%22parsedDate%22%3A%222021-05-11%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EHashimoto%2C%20H.%2C%20Kasteleiner%2C%20P.%2C%20Kressin%2C%20J.%2C%20M%26%23xFC%3Bller%2C%20F.%2C%20B%26%23xFC%3Bhring%2C%20H.-J.%2C%20Handgretinger%2C%20R.%2C%20%26amp%3B%20Schilbach%2C%20K.%20%282021%29.%20Removal%20of%20CD276%20%2B%20cells%20from%20haploidentical%20memory%20T-cell%20grafts%20significantly%20lowers%20the%20risk%20of%20GVHD.%20%3Ci%3EBone%20Marrow%20Transplantation%3C%5C%2Fi%3E%2C%201%26%23x2013%3B19.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41409-021-01307-9%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41409-021-01307-9%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DMCZDKC6N%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Removal%20of%20CD276%20%2B%20cells%20from%20haploidentical%20memory%20T-cell%20grafts%20significantly%20lowers%20the%20risk%20of%20GVHD%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hisayoshi%22%2C%22lastName%22%3A%22Hashimoto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%22%2C%22lastName%22%3A%22Kasteleiner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakob%22%2C%22lastName%22%3A%22Kressin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Friederike%22%2C%22lastName%22%3A%22M%5Cu00fcller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans-J%5Cu00f6rg%22%2C%22lastName%22%3A%22B%5Cu00fchring%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rupert%22%2C%22lastName%22%3A%22Handgretinger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%22%2C%22lastName%22%3A%22Schilbach%22%7D%5D%2C%22abstractNote%22%3A%22Detrimental%20graft-versus-host%20disease%20%28GVHD%29%20still%20remains%20a%20major%20cause%20of%20death%20in%20hematopoietic%20stem%20cell%20transplantation%20%28HSCT%29.%20The%20recently%20explored%20depletion%20of%20naive%20cells%20from%20mobilized%20grafts%20%28CD45RA%20depletion%29%20has%20shown%20considerable%20promise%2C%20yet%20is%20unable%20to%20eliminate%20the%20incidence%20of%20GVHD.%20Analysis%20of%20CD45RA-depleted%20haploidentical%20mixed%20lymphocytes%20culture%20%28haplo-MLC%29%20revealed%20insufficient%20suppression%20of%20alloresponses%20in%20the%20CD4%2B%20compartment%20and%20identified%20CD276%20as%20a%20marker%20for%20alloreactive%20memory%20Th1%20T%20cells.%20Conclusively%2C%20depleting%20CD276%2B%20cells%20from%20CD45RA-depleted%20haplo-MLC%20significantly%20attenuated%20alloreactivity%20to%20recipient%20cells%20while%20increasing%20antiviral%20reactivity%20and%20maintaining%20anti-third%20party%20reactivity%20in%20vitro.%20To%20evaluate%20these%20findings%20in%20vivo%2C%20bulk%2C%20CD45RA-depleted%2C%20or%20CD45RA%5C%2FCD276-depleted%20CD4%2B%20T%20cells%20from%20HLA-DR4negative%20healthy%20humans%20were%20transplanted%20into%20NSG-Ab%5Cu00b0DR4%20mice%2C%20a%20sensitive%20human%20allo-GVHD%20model.%20Compellingly%2C%20CD45RA%5C%2FCD276-depleted%20grafts%20from%20HLA-DR4negative%20donors%20or%20in%20vivo%20depletion%20of%20CD276%2B%20cells%20after%20transplant%20of%20HLA-DR4negative%20memory%20CD4%20T%20cells%20significantly%20delay%20the%20onset%20of%20GVHD%20symptoms%20and%20significantly%20alleviate%20its%20severity%20in%20NSG-Ab%5Cu00b0DR4%20mice.%20The%20clinical%20courses%20correlated%20with%20diminished%20Th1-cytokine%20secretion%20and%20downregulated%20CXCR6%20expression%20of%20engrafted%20peripheral%20T%20cells.%20Collectively%2C%20mismatched%20HLA-mediated%20GVHD%20can%20be%20controlled%20by%20depleting%20recipient-specific%20CD276%2B%20alloreacting%20T%20cells%20from%20the%20graft%2C%20highlighting%20its%20application%20in%20haplo-HSCT.%22%2C%22date%22%3A%222021-05-11%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41409-021-01307-9%22%2C%22ISSN%22%3A%221476-5365%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41409-021-01307-9%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-05-11T18%3A08%3A14Z%22%7D%7D%5D%7D
Hashimoto, H., Kasteleiner, P., Kressin, J., Müller, F., Bühring, H.-J., Handgretinger, R., & Schilbach, K. (2021). Removal of CD276 + cells from haploidentical memory T-cell grafts significantly lowers the risk of GVHD. Bone Marrow Transplantation, 1–19. https://doi.org/10.1038/s41409-021-01307-9 Cite
