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Pulmonary Cell NewsScientists showed that obesity led to neutrophil-dependent impairment of vascular integrity through loss of endothelial adhesions, enabling cancer cell extravasation into the lung.
[Nature Cancer]
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McDowell, S. A. C., Luo, R. B. E., Arabzadeh, A., Doré, S., Bennett, N. C., Breton, V., Karimi, E., Rezanejad, M., Yang, R. R., Lach, K. D., Issac, M. S. M., Samborska, B., Perus, L. J. M., Moldoveanu, D., Wei, Y., Fiset, B., Rayes, R. F., Watson, I. R., Kazak, L., … Quail, D. F. (2021). Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration. Nature Cancer, 1–18. https://doi.org/10.1038/s43018-021-00194-9 Cite
