Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity

The mechanisms by which regulatory T (Treg) cells differentially control allergic and autoimmune responses remain unclear. Researchers showed that Treg cells in food allergy had decreased expression of transforming growth factor beta 1 (TGF-β1) because of interleukin-4- and signal transducer and activator of transciription-6-dependent inhibition of Tgfb1 transcription.