Inhibition of Host Ogr1 Enhances Effector CD8+ T-cell Function by Modulating Acidic Microenvironment

By
Justin.choi
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0
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A highly acidified microenvironment of melanoma induced the expression of G-protein-coupled receptor in T cells, which weakened their effective function and promote tumor growth.
[Cancer Gene Therapy]
Cao, L., Li, W., Yang, X., Zhang, W., Li, M., Zhang, H., Qin, C., Chen, X., & Gao, R. (2021). Inhibition of host Ogr1 enhances effector CD8+ T-cell function by modulating acidic microenvironment. Cancer Gene Therapy, 1–12. https://doi.org/10.1038/s41417-021-00354-0 Cite
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