The Development of a Functional Human Small Intestinal Epithelium Model for Drug Absorption

By
Justin.choi
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Researchers developed a reproducible two-step protocol to induce human pluripotent stem cells to differentiate into highly expandable human intestinal epithelial cells (hIECs) progenitors and a functional hIEC monolayer exhibiting intestinal molecular features, cell type diversity, and high activities of intestinal transporters and metabolic enzymes such as cytochrome P450 3A4.
[Science Advances]
Kwon, O., Jung, K. B., Lee, K.-R., Son, Y. S., Lee, H., Kim, J.-J., Kim, K., Lee, S., Song, Y.-K., Jung, J., Park, K., Kim, D.-S., Son, M. J., Lee, M.-O., Han, T.-S., Cho, H.-S., Oh, S. J., Chung, H., Kim, S.-H., … Son, M.-Y. (2021). The development of a functional human small intestinal epithelium model for drug absorption. Science Advances, 7(23), eabh1586. https://doi.org/10.1126/sciadv.abh1586 Cite
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