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Pulmonary Cell NewsInvestigators found that in KrasG12D-expressing endometrial organoids, Pten knockdown did not confer tumorigenicity, but Cdkn2a knockdown or Trp53 deletion led to the development of carcinosarcoma, a rare, aggressive tumor comprising both carcinoma and sarcoma.
[Oncogenesis]
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Maru, Y., Tanaka, N., Tatsumi, Y., Nakamura, Y., Itami, M., & Hippo, Y. (2021). Kras activation in endometrial organoids drives cellular transformation and epithelial-mesenchymal transition. Oncogenesis, 10(6), 1–12. https://doi.org/10.1038/s41389-021-00337-8 Cite
