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Pulmonary Cell NewsInvestigators developed a potent inhibitor of cyclin-dependent kinase 7 (CDK7), designated YPN-005, and determined whether it showed any anticancer effects in small cell lung cancer (SCLC), cells, cisplatin or etoposide-resistant cells, or organoids derived from SCLC patients.
[European Journal of Pharmacology]
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Choi, Y. J., Lee, H., Kim, D.-S., Kim, D. H., Kang, M.-H., Cho, Y.-H., Choi, C.-M., Yoo, J., Lee, K.-O., Choi, E. K., Lee, J. C., & Rho, J. K. (2021). Discovery of a novel CDK7 inhibitor YPN-005 in small cell lung cancer. European Journal of Pharmacology, 907, 174298. https://doi.org/10.1016/j.ejphar.2021.174298 Cite
