cyclin D1

[Reproductive Toxicology] The potential effect of fludioxonil on cardiac differentiation was evaluated in mouse ESCs. Exposure to fludioxonil resulted in reduced size of mouse embryoid bodies and induced increasing expression levels of the pluripotency markers Oct4, Sox2 and Nanog.

[American Journal of Physiology-Heart and Circulatory Physiology] The authors examined the role of Sirtuin1 (Sirt1) in Angiotensin II (Ang II)-induced overexpression of Giα proteins and hyperproliferation of aortic vascular smooth muscle cells (VSMCs). Ang II treatment of VSMCs increased the expression of Sirt1 which was attenuated by AT1 and AT2 receptor antagonists, losartan and PD123319 respectively.

[Molecular Therapy] AAV9-mediated cardiac specific ADAR2 overexpression attenuated acute myocardial infarction (MI), MI remodeling and doxorubicin-induced cardiotoxicity. In vitro, overexpression of ADAR2 inhibited doxorubicin-induced cardiomyocyte apoptosis but also induced neonatal rat cardiomyocyte proliferation.

[Acta Biochimica et Biophysica Sinica] Exosome marker protein levels were increased in the exosomes derived from human umbilical cord MSCs (hUMSC-Ex) compared with those in hUMSC suspension, indicating that exosomes were successfully isolated from hUMSCs.

[Ultrasonics Sonochemistry] Ultrasound-assisted extract of yeast was found to effectively inhibit melanoma cell growth and proliferation as well as the expression of cyclin D1 and c-myc, in vitro.

[Cell Death & Disease] Scientists clarified the role of KLHL38 in non-small cell lung cancer (NSCLC). KLHL38 expression was evaluated in tumor and adjacent normal tissues from 241 patients with NSCLC using immunohistochemistry and real-time PCR, and its association with clinicopathological parameters was analyzed.