epithelial cells

[Pathology International] Immunostaining was performed using liver sections of Caroli disease and polycystic liver disease, and the results were compared with those of congenital hepatic fibrosisand von Meyenburg complex.

[Oncogenesis] Investigators found that in KrasG12D-expressing endometrial organoids, Pten knockdown did not confer tumorigenicity, but Cdkn2a knockdown or Trp53 deletion led to the development of carcinosarcoma, a rare, aggressive tumor comprising both carcinoma and sarcoma.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers showed that Duox1 promoted antiviral innate immunity in vivo. Upon influenza airway challenge, Duox1−/− mice had enhanced mortality, morbidity, and impaired lung viral clearance.

[Oncogene] Researchers found that loss of lung cell lineage and gain of stem cell-like characteristics, along with mutator and immune evasion phenotypes, explained the aggressive behavior of a specific subset of lung adenocarcinoma (LUAD) that was called C1-LUAD, including early-stage disease.

[Laboratory Investigation] In vitro, epithelial-mesenchymal transition (EMT) was induced by the administration of transforming growth factor-β1 in a human alveolar epithelial cell line.

[Scientific Reports] Researchers hypothesized that the autophagy pathway was required for resolution of mucous metaplasia by eliminating excess non-secreted intracellular mucin granules.