NF-κB

[Science Advances] In this proof-of-concept study, the authors successfully established organoids from seven chordoma tumor samples obtained from five patients presenting with tumors in different sites and stages of disease.

[Cell Death & Disease] Investigators found that inhibition of G protein-coupled receptor 4 (GPR4) with the antagonist NE52-QQ57 ameliorated osteoarthritis progression in mice, promoted ECM production, and protected cartilage from degradation in human articular cartilage explants.

[Journal of Cell Biology] Scientists devised a straightforward bioengineered neural organoid culture approach entailing transcription factor–driven direct differentiation of neurons and astrocytes from human PSC combined with genetically encoded tools for dual cell-selective activation.

[Cell Death Discovery] Within LPS-treated MODE-K cells, METTL3 knockdown promoted cell viability, inhibited cell apoptosis, decreased apoptotic caspase3/9 cleavage, and decreased the levels of proinflammatory cytokines and inflammatory enzymes

[Phytotherapy Research] Scientists investigated the underlying mechanism and pharmacological effect of rhamnazin against pulmonary disorders.

[Science Translational Medicine] Investigators examined human atopic dermatitis (AD) skin samples and found that human AD fibroblasts also overexpressed C-C motif chemokine ligand 11 (CCL11) and that perturbation of Ikkb–NF-κB in primary human dermal fibroblasts up-regulated CCL11.