Elimination of Nf-kB Signaling in Vimentin+ Stromal Cells Attenuates Tumorigenesis in a Mouse Model of Barrett Esophagus

By
Justin.choi
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To analyze the effect of NF-kB signaling in myofibroblasts (MFs), researchers crossed L2-IL-1B mice to tamoxifen inducible Vim-Cre mice and floxed RelA mice to specifically eliminate NF-kB signaling in MF. The interaction of epithelial cells and stromal cells was further analyzed in mouse Barrett Esophagus organoids and patient-derived human organoids.
[Carcinogenesis]
Anand, A., Fang, H.-Y., Mohammad Shahi, D., Ingermann, J., Baumeister, T., Strangmann, J., Wang, T. C., & Quante, M. (n.d.). Elimination of Nf-kB signaling in Vimentin+ stromal cells attenuates tumorigenesis in a mouse model of Barrett Esophagus. Carcinogenesis. https://doi.org/10.1093/carcin/bgaa109 Cite
Abstract