Nuclear Partitioning of Prohibitin 1 Inhibits Wnt/β-Catenin-Dependent Intestinal Tumorigenesis

Using mice with inducible intestinal epithelial cell-specific deletion of Phb1 and mice with IEC-specific overexpression of Phb1, investigators demonstrated that IEC-specific PHB1 combats intestinal tumorigenesis in the Apc^Min/+ mouse model by inhibiting Wnt/β-catenin signaling.