COVID-19 Immune Signatures Reveal Stable Antiviral T Cell Function despite Declining Humoral Responses

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The role of SARS-CoV-2-specific T cell immunity, its relationship to antibodies, and pre-existing immunity against endemic coronaviruses (huCoV), which has been hypothesized to be protective, were investigated in healthy donors, recovered, and active COVID-19 patients.
[Immunity]
Bonifacius, A., Tischer-Zimmermann, S., Dragon, A. C., Gussarow, D., Vogel, A., Krettek, U., Gödecke, N., Yilmaz, M., Kraft, A. R. M., Hoeper, M. M., Pink, I., Schmidt, J. J., Li, Y., Welte, T., Maecker-Kolhoff, B., Martens, J., Berger, M. M., Lobenwein, C., Stankov, M. V., … Eiz-Vesper, B. (2021). COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses. Immunity, 54(2), 340-354.e6. https://doi.org/10.1016/j.immuni.2021.01.008 Cite
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