Alternative Splicing of the Inhibitory Immune Checkpoint Receptor SLAMF6 Generates a Dominant Positive Form, Boosting T Cell Effector Functions

By
Justin.choi
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Scientists showed that in humans, SLAMF6 has three splice isoforms involving its V-domain. Although the canonical receptor inhibited T-cell activation through SAP recruitment, the short isoform SLAMF6∆17-65 had a strong agonistic effect. T
[Cancer Immunology Research]
Hajaj, E., Zisman, E., Tzaban, S., Merims, S., Cohen, J., Klein, S., Frankenburg, S., Sade-Feldman, M., Tabach, Y., Yizhak, K., Navon, A., Stepensky, P., Hacohen, N., Peretz, T., Veillette, A., Karni, R., Eisenberg, G., & Lotem, M. (2021). Alternative splicing of the inhibitory immune checkpoint receptor SLAMF6 generates a dominant positive form, boosting T cell effector functions. Cancer Immunology Research. https://doi.org/10.1158/2326-6066.CIR-20-0800 Cite
Abstract