Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsIn vitro, neonatal ventricle cardiomyocyte hypoxia/reoxygenation model was constructed to mimic myocardial ischemia/reperfusion. PSMB4 silence promoted cardiomyocyte apoptosis and IκBα expression, inhibited the activation of NF-κB.
[Journal of Molecular Histology]
6445218 {6445218:2MXMPVR8} apa 50 1 162021 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-506a88d4b08763fe0ceb7751de683ad8%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%222MXMPVR8%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Yang%20et%20al.%22%2C%22parsedDate%22%3A%222021-05-05%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EYang%2C%20C.%2C%20Yu%2C%20P.%2C%20Yang%2C%20F.%2C%20He%2C%20Q.%2C%20Jiang%2C%20B.%2C%20Zheng%2C%20L.%2C%20Wang%2C%20Q.%2C%20Wang%2C%20J.%2C%20Qiu%2C%20H.%2C%20Wang%2C%20H.%2C%20%26amp%3B%20Zhang%2C%20L.%20%282021%29.%20PSMB4%20inhibits%20cardiomyocyte%20apoptosis%20via%20activating%20NF-%26%23x3BA%3BB%20signaling%20pathway%20during%20myocardial%20ischemia%5C%2Freperfusion%20injury.%20%3Ci%3EJournal%20of%20Molecular%20Histology%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10735-021-09977-x%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10735-021-09977-x%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3D2MXMPVR8%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22PSMB4%20inhibits%20cardiomyocyte%20apoptosis%20via%20activating%20NF-%5Cu03baB%20signaling%20pathway%20during%20myocardial%20ischemia%5C%2Freperfusion%20injury%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chen%22%2C%22lastName%22%3A%22Yang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pengyi%22%2C%22lastName%22%3A%22Yu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fangfang%22%2C%22lastName%22%3A%22Yang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qian%22%2C%22lastName%22%3A%22He%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bo%22%2C%22lastName%22%3A%22Jiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Liang%22%2C%22lastName%22%3A%22Zheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qianyun%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jun%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hui%22%2C%22lastName%22%3A%22Qiu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hui%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lei%22%2C%22lastName%22%3A%22Zhang%22%7D%5D%2C%22abstractNote%22%3A%22Myocardial%20ischemia%5C%2Freperfusion%20%28I%5C%2FR%29%20injury%20induces%20cardiomyocyte%20apoptosis%20to%20deteriorate%20heart%20function.%20Thus%2C%20how%20to%20inhibit%20cardiomyocyte%20apoptosis%20is%20the%20focus%20of%20recent%20researches.%20Proteasome%20family%20member%20PSMB4%20%28proteasome%20subunit%20beta%20type-4%29%20promotes%20cell%20survival.%20The%20relationship%20between%20PSMB4%20and%20cardiomyocyte%20apoptosis%20during%20myocardial%20I%5C%2FR%20is%20unknown.%20In%20this%20study%2C%20PSMB4%20expression%20increased%20in%20rat%20myocardial%20I%5C%2FR%20model%2C%20positively%20correlated%20with%20cleaved%20caspase-3%20expression%2C%20negatively%20correlated%20with%20Bcl-2%20expression.%20In%20vitro%2C%20neonatal%20ventricle%20cardiomyocyte%20hypoxia%5C%2Freoxygenation%20%28H%5C%2FR%29%20model%20was%20constructed%20to%20mimic%20myocardial%20I%5C%2FR.%20PSMB4%20silence%20promoted%20cardiomyocyte%20apoptosis%20and%20I%5Cu03baB%5Cu03b1%20expression%2C%20inhibited%20the%20activation%20of%20NF-%5Cu03baB.%20On%20the%20contrary%2C%20PSMB4%20overexpession%20inhibited%20cardiomyocyte%20apoptosis%20and%20I%5Cu03baB%5Cu03b1%20expression%2C%20promoted%20the%20activation%20of%20NF-%5Cu03baB.%20Additionally%2C%20PSMB4-I%5Cu03baB%5Cu03b1%20interaction%20was%20identified%2C%20suggesting%20that%20PSMB4%20might%20participate%20in%20the%20proteasome%20dependent%20degradation%20of%20I%5Cu03baB%5Cu03b1.%20The%20data%20indicates%20that%20PSMB4%20inhibits%20cardiomyocyte%20apoptosis%20via%20activating%20NF-%5Cu03baB%20signaling%20pathway%20during%20myocardial%20I%5C%2FR%2C%20which%20can%20supply%20novel%20molecular%20target%20for%20the%20treatment%20of%20ischemic%20heart%20disease.%22%2C%22date%22%3A%222021-05-05%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10735-021-09977-x%22%2C%22ISSN%22%3A%221567-2387%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10735-021-09977-x%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-05-08T06%3A08%3A30Z%22%7D%7D%5D%7D
Yang, C., Yu, P., Yang, F., He, Q., Jiang, B., Zheng, L., Wang, Q., Wang, J., Qiu, H., Wang, H., & Zhang, L. (2021). PSMB4 inhibits cardiomyocyte apoptosis via activating NF-κB signaling pathway during myocardial ischemia/reperfusion injury. Journal of Molecular Histology. https://doi.org/10.1007/s10735-021-09977-x Cite
