Apoptotic Mesenchymal Stromal Cells Support Osteoclastogenesis While Inhibiting Multinucleated Giant Cells Formation In Vitro

Scientists focused on the communication from MSCs towards osteoclasts-like cells in vitro. MSCs seeded on a calcium-phosphate biomaterial or undergoing induced apoptosis produced a conditioned media favoring the development of osteoclasts from human CD14+ monocytes.