Scientists summarize the use of different human cell populations for preclinical and clinical tissue-engineered skin substitutes under research, remarking their strengths and limitations and discuss the future perspectives, which could be useful for wound healing purposes.
[NPJ Regenerative Medicine]
7753456 26CWUHMA items 1 apa 0 default asc 1 163658 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-bfb9b37aaa48d9686cabe81d525c19c2%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%2226CWUHMA%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Sierra-S%5Cu00e1nchez%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-17%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESierra-S%26%23xE1%3Bnchez%2C%20%26%23xC1%3B.%2C%20Kim%2C%20K.%20H.%2C%20Blasco-Morente%2C%20G.%2C%20%26amp%3B%20Arias-Santiago%2C%20S.%20%282021%29.%20Cellular%20human%20tissue-engineered%20skin%20substitutes%20investigated%20for%20deep%20and%20difficult%20to%20heal%20injuries.%20%3Ci%3ENpj%20Regenerative%20Medicine%3C%5C%2Fi%3E%2C%20%3Ci%3E6%3C%5C%2Fi%3E%281%29%2C%201%26%23x2013%3B23.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41536-021-00144-0%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41536-021-00144-0%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3D26CWUHMA%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cellular%20human%20tissue-engineered%20skin%20substitutes%20investigated%20for%20deep%20and%20difficult%20to%20heal%20injuries%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22%5Cu00c1lvaro%22%2C%22lastName%22%3A%22Sierra-S%5Cu00e1nchez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kevin%20H.%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gonzalo%22%2C%22lastName%22%3A%22Blasco-Morente%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Salvador%22%2C%22lastName%22%3A%22Arias-Santiago%22%7D%5D%2C%22abstractNote%22%3A%22Wound%20healing%20is%20an%20important%20function%20of%20skin%3B%20however%2C%20after%20significant%20skin%20injury%20%28burns%29%20or%20in%20certain%20dermatological%20pathologies%20%28chronic%20wounds%29%2C%20this%20important%20process%20can%20be%20deregulated%20or%20lost%2C%20resulting%20in%20severe%20complications.%20To%20avoid%20these%2C%20studies%20have%20focused%20on%20developing%20tissue-engineered%20skin%20substitutes%20%28TESSs%29%2C%20which%20attempt%20to%20replace%20and%20regenerate%20the%20damaged%20skin.%20Autologous%20cultured%20epithelial%20substitutes%20%28CESs%29%20constituted%20of%20keratinocytes%2C%20allogeneic%20cultured%20dermal%20substitutes%20%28CDSs%29%20composed%20of%20biomaterials%20and%20fibroblasts%20and%20autologous%20composite%20skin%20substitutes%20%28CSSs%29%20comprised%20of%20biomaterials%2C%20keratinocytes%20and%20fibroblasts%2C%20have%20been%20the%20most%20studied%20clinical%20TESSs%2C%20reporting%20positive%20results%20for%20different%20pathological%20conditions.%20However%2C%20researchers%5Cu2019%20purpose%20is%20to%20develop%20TESSs%20that%20resemble%20in%20a%20better%20way%20the%20human%20skin%20and%20its%20wound%20healing%20process.%20For%20this%20reason%2C%20they%20have%20also%20evaluated%20at%20preclinical%20level%20the%20incorporation%20of%20other%20human%20cell%20types%20such%20as%20melanocytes%2C%20Merkel%20and%20Langerhans%20cells%2C%20skin%20stem%20cells%20%28SSCs%29%2C%20induced%20pluripotent%20stem%20cells%20%28iPSCs%29%20or%20mesenchymal%20stem%20cells%20%28MSCs%29.%20Among%20these%2C%20MSCs%20have%20been%20also%20reported%20in%20clinical%20studies%20with%20hopeful%20results.%20Future%20perspectives%20in%20the%20field%20of%20human-TESSs%20are%20focused%20on%20improving%20in%20vivo%20animal%20models%2C%20incorporating%20immune%20cells%2C%20designing%20specific%20niches%20inside%20the%20biomaterials%20to%20increase%20stem%20cell%20potential%20and%20developing%20three-dimensional%20bioprinting%20strategies%2C%20with%20the%20final%20purpose%20of%20increasing%20patient%5Cu2019s%20health%20care.%20In%20this%20review%20we%20summarize%20the%20use%20of%20different%20human%20cell%20populations%20for%20preclinical%20and%20clinical%20TESSs%20under%20research%2C%20remarking%20their%20strengths%20and%20limitations%20and%20discuss%20the%20future%20perspectives%2C%20which%20could%20be%20useful%20for%20wound%20healing%20purposes.%22%2C%22date%22%3A%222021-06-17%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41536-021-00144-0%22%2C%22ISSN%22%3A%222057-3995%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41536-021-00144-0%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%22DUPVZUHA%22%5D%2C%22dateModified%22%3A%222021-06-17T16%3A55%3A49Z%22%7D%7D%5D%7D
Sierra-Sánchez, Á., Kim, K. H., Blasco-Morente, G., & Arias-Santiago, S. (2021). Cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries. Npj Regenerative Medicine, 6(1), 1–23. https://doi.org/10.1038/s41536-021-00144-0 Cite