Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsResearchers reported that ventrolateral medulla (VLM) catecholaminergic neurons in the mouse brain were activated in tumor-bearing mice and the activity of these neurons significantly altered tumor growth in multiple syngeneic and spontaneous mouse tumor models.
[Proceedings of the National Academy of Sciences of the United States of America]
7753456 TUTZS2Z6 items 1 apa 0 default asc 1 164294 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-fe179b8681e5981c0242947b59dbcd0a%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22TUTZS2Z6%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zhang%20et%20al.%22%2C%22parsedDate%22%3A%222021-07-13%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EZhang%2C%20Z.%2C%20Li%2C%20Y.%2C%20Lv%2C%20X.%2C%20Zhao%2C%20L.%2C%20%26amp%3B%20Wang%2C%20X.%20%282021%29.%20VLM%20catecholaminergic%20neurons%20control%20tumor%20growth%20by%20regulating%20CD8%2B%20T%20cells.%20%3Ci%3EProceedings%20of%20the%20National%20Academy%20of%20Sciences%3C%5C%2Fi%3E%2C%20%3Ci%3E118%3C%5C%2Fi%3E%2828%29.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1073%5C%2Fpnas.2103505118%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1073%5C%2Fpnas.2103505118%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3DTUTZS2Z6%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22VLM%20catecholaminergic%20neurons%20control%20tumor%20growth%20by%20regulating%20CD8%2B%20T%20cells%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ze%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yehua%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xueyuan%22%2C%22lastName%22%3A%22Lv%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Linlin%22%2C%22lastName%22%3A%22Zhao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaodong%22%2C%22lastName%22%3A%22Wang%22%7D%5D%2C%22abstractNote%22%3A%22%3Cp%3EIt%20is%20known%20that%20tumor%20growth%20can%20be%20influenced%20by%20the%20nervous%20system.%20It%20is%20not%20known%2C%20however%2C%20if%20tumors%20communicate%20directly%20with%20the%20central%20nervous%20system%20%28CNS%29%20or%20if%20such%20interactions%20may%20impact%20tumor%20growth.%20Here%2C%20we%20report%20that%20ventrolateral%20medulla%20%28VLM%29%20catecholaminergic%20%28CA%29%20neurons%20in%20the%20mouse%20brain%20are%20activated%20in%20tumor-bearing%20mice%20and%20the%20activity%20of%20these%20neurons%20significantly%20alter%20tumor%20growth%20in%20multiple%20syngeneic%20and%20spontaneous%20mouse%20tumor%20models.%20Specific%20ablation%20of%20VLM%20CA%20neurons%20by%20a%20dopamine-%5Cu03b2-hydroxylase%20%28DBH%29%20promotor-activated%20apoptosis-promoting%20caspase-3%20in%20%3Ci%3EDbh-Cre%3C%5C%2Fi%3E%20mice%20as%20well%20as%20inhibition%20of%20these%20neurons%20by%20a%20chemogenetic%20method%20slowed%20tumor%20progression.%20Consistently%2C%20chemogenetic%20activation%20of%20VLM%20CA%20neurons%20promoted%20tumor%20growth.%20The%20tumor%20inhibition%20effect%20of%20VLM%20CA%20neuron%20ablation%20is%20mitigated%20in%20%3Ci%3EDbh-Cre%3BRag1%3C%5C%2Fi%3E%3Csup%3E%3Ci%3E%5Cu2212%5C%2F%5Cu2212%3C%5C%2Fi%3E%3C%5C%2Fsup%3E%20mice%2C%20indicating%20that%20this%20regulatory%20effect%20is%20mediated%20by%20the%20adaptive%20immune%20system.%20Specific%20depletion%20of%20CD8%3Csup%3E%2B%3C%5C%2Fsup%3E%20T%20cells%20using%20an%20anti-CD8%3Csup%3E%2B%3C%5C%2Fsup%3E%20antibody%20also%20mitigated%20the%20tumor%20suppression%20resulting%20from%20the%20VLM%20CA%20neuron%20ablation.%20Finally%2C%20we%20showed%20that%20the%20VLM%20CA%20neuronal%20ablation%20had%20an%20additive%20antitumor%20effect%20with%20paclitaxel%20treatment.%20Collectively%2C%20our%20study%20uncovered%20the%20role%20of%20VLM%20CA%20neurons%20in%20the%20mouse%20brain%20in%20controlling%20tumor%20growth%20in%20the%20mouse%20body.%3C%5C%2Fp%3E%22%2C%22date%22%3A%222021%5C%2F07%5C%2F13%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1073%5C%2Fpnas.2103505118%22%2C%22ISSN%22%3A%220027-8424%2C%201091-6490%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.pnas.org%5C%2Fcontent%5C%2F118%5C%2F28%5C%2Fe2103505118%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-07-07T15%3A20%3A03Z%22%7D%7D%5D%7D
Zhang, Z., Li, Y., Lv, X., Zhao, L., & Wang, X. (2021). VLM catecholaminergic neurons control tumor growth by regulating CD8+ T cells. Proceedings of the National Academy of Sciences, 118(28). https://doi.org/10.1073/pnas.2103505118 Cite
