Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsScientists reported injectable biomaterial vaccines that triggered potent humoral and T-cell responses to bacterial antigens by recruiting, reprogramming and releasing dendritic cells.
[Nature Biomedical Engineering]
6445218 {6445218:8BXRNW2F} apa 50 1 164383 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-f986eeb0088d91edf14a963d36eb3187%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%228BXRNW2F%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Super%20et%20al.%22%2C%22parsedDate%22%3A%222021-07-08%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESuper%2C%20M.%2C%20Doherty%2C%20E.%20J.%2C%20Cartwright%2C%20M.%20J.%2C%20Seiler%2C%20B.%20T.%2C%20Langellotto%2C%20F.%2C%20Dimitrakakis%2C%20N.%2C%20White%2C%20D.%20A.%2C%20Stafford%2C%20A.%20G.%2C%20Karkada%2C%20M.%2C%20Graveline%2C%20A.%20R.%2C%20Horgan%2C%20C.%20L.%2C%20Lightbown%2C%20K.%20R.%2C%20Urena%2C%20F.%20R.%2C%20Yeager%2C%20C.%20D.%2C%20Rifai%2C%20S.%20A.%2C%20Dellacherie%2C%20M.%20O.%2C%20Li%2C%20A.%20W.%2C%20Leese-Thompson%2C%20C.%2C%20Ijaz%2C%20H.%2C%20%26%23x2026%3B%20Mooney%2C%20D.%20J.%20%282021%29.%20Biomaterial%20vaccines%20capturing%20pathogen-associated%20molecular%20patterns%20protect%20against%20bacterial%20infections%20and%20septic%20shock.%20%3Ci%3ENature%20Biomedical%20Engineering%3C%5C%2Fi%3E%2C%201%26%23x2013%3B11.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41551-021-00756-3%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41551-021-00756-3%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3D8BXRNW2F%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Biomaterial%20vaccines%20capturing%20pathogen-associated%20molecular%20patterns%20protect%20against%20bacterial%20infections%20and%20septic%20shock%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Super%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edward%20J.%22%2C%22lastName%22%3A%22Doherty%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20J.%22%2C%22lastName%22%3A%22Cartwright%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%20T.%22%2C%22lastName%22%3A%22Seiler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernanda%22%2C%22lastName%22%3A%22Langellotto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nikolaos%22%2C%22lastName%22%3A%22Dimitrakakis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Des%20A.%22%2C%22lastName%22%3A%22White%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%20G.%22%2C%22lastName%22%3A%22Stafford%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mohan%22%2C%22lastName%22%3A%22Karkada%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amanda%20R.%22%2C%22lastName%22%3A%22Graveline%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caitlin%20L.%22%2C%22lastName%22%3A%22Horgan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kayla%20R.%22%2C%22lastName%22%3A%22Lightbown%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%20R.%22%2C%22lastName%22%3A%22Urena%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chyenne%20D.%22%2C%22lastName%22%3A%22Yeager%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sami%20A.%22%2C%22lastName%22%3A%22Rifai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxence%20O.%22%2C%22lastName%22%3A%22Dellacherie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aileen%20W.%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Collin%22%2C%22lastName%22%3A%22Leese-Thompson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hamza%22%2C%22lastName%22%3A%22Ijaz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amanda%20R.%22%2C%22lastName%22%3A%22Jiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vasanth%22%2C%22lastName%22%3A%22Chandrasekhar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Justin%20M.%22%2C%22lastName%22%3A%22Scott%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shanda%20L.%22%2C%22lastName%22%3A%22Lightbown%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Donald%20E.%22%2C%22lastName%22%3A%22Ingber%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20J.%22%2C%22lastName%22%3A%22Mooney%22%7D%5D%2C%22abstractNote%22%3A%22Most%20bacterial%20vaccines%20work%20for%20a%20subset%20of%20bacterial%20strains%20or%20require%20the%20modification%20of%20the%20antigen%20or%20isolation%20of%20the%20pathogen%20before%20vaccine%20development.%20Here%20we%20report%20injectable%20biomaterial%20vaccines%20that%20trigger%20potent%20humoral%20and%20T-cell%20responses%20to%20bacterial%20antigens%20by%20recruiting%2C%20reprogramming%20and%20releasing%20dendritic%20cells.%20The%20vaccines%20are%20assembled%20from%20regulatorily%20approved%20products%20and%20consist%20of%20a%20scaffold%20with%20absorbed%20granulocyte-macrophage%20colony-stimulating%20factor%20and%20CpG-rich%20oligonucleotides%20incorporating%20superparamagnetic%20microbeads%20coated%20with%20the%20broad-spectrum%20opsonin%20Fc-mannose-binding%20lectin%20for%20the%20magnetic%20capture%20of%20pathogen-associated%20molecular%20patterns%20from%20inactivated%20bacterial-cell-wall%20lysates.%20The%20vaccines%20protect%20mice%20against%20skin%20infection%20with%20methicillin-resistant%20Staphylococcus%20aureus%2C%20mice%20and%20pigs%20against%20septic%20shock%20from%20a%20lethal%20Escherichia%20coli%20challenge%20and%2C%20when%20loaded%20with%20pathogen-associated%20molecular%20patterns%20isolated%20from%20infected%20animals%2C%20uninfected%20animals%20against%20a%20challenge%20with%20different%20E.%20coli%20serotypes.%20The%20strong%20immunogenicity%20and%20low%20incidence%20of%20adverse%20events%2C%20a%20modular%20manufacturing%20process%2C%20and%20the%20use%20of%20components%20compatible%20with%20current%20good%20manufacturing%20practice%20could%20make%20this%20vaccine%20technology%20suitable%20for%20responding%20to%20bacterial%20pandemics%20and%20biothreats.%22%2C%22date%22%3A%222021-07-08%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41551-021-00756-3%22%2C%22ISSN%22%3A%222157-846X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41551-021-00756-3%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-07-08T21%3A25%3A47Z%22%7D%7D%5D%7D
Super, M., Doherty, E. J., Cartwright, M. J., Seiler, B. T., Langellotto, F., Dimitrakakis, N., White, D. A., Stafford, A. G., Karkada, M., Graveline, A. R., Horgan, C. L., Lightbown, K. R., Urena, F. R., Yeager, C. D., Rifai, S. A., Dellacherie, M. O., Li, A. W., Leese-Thompson, C., Ijaz, H., … Mooney, D. J. (2021). Biomaterial vaccines capturing pathogen-associated molecular patterns protect against bacterial infections and septic shock. Nature Biomedical Engineering, 1–11. https://doi.org/10.1038/s41551-021-00756-3 Cite
