Investigators used an MHC Associated Peptide Proteomics assay to identify SaCas9 peptides presented by MHC Class II (MHC-II) proteins on dendritic cells.
[Nature Communications]
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Simhadri, V. L., Hopkins, L., McGill, J. R., Duke, B. R., Mukherjee, S., Zhang, K., & Sauna, Z. E. (2021). Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4+ T-cells. Nature Communications, 12(1), 5090. https://doi.org/10.1038/s41467-021-25414-9 Cite