miR-181a Is a Novel Player in the STAT3-Mediated Survival Network of TCRαβ⁺ CD8⁺ T Large Granular Lymphocyte Leukemia

By using TL1, a human T-LGL cell line, the authors could show that miR-181a was an actor in T-LGL leukemia, driving STAT3 activation by SOCS3 inhibition and ERK1/2 phosphorylation by DUSP6 inhibition and verified this mechanism in an independent cell line.