Mimicking Native Liver Lobule Microarchitecture In Vitro with Parenchymal and Non-Parenchymal Cells Using 3D Bioprinting for Drug Toxicity and Drug Screening Applications

A physiologically relevant human vascularized liver model was bioprinted with a novel liver extracellular matrix-based bioink laden with human adipose mesenchymal stem cell-derived hepatocyte-like cells, human umbilical vein endothelial cells, and human hepatic stellate cells.