Single-Cell Characterization of Leukemic and Non-Leukemic Immune Repertoires in CD8⁺ T Cell Large Granular Lymphocytic Leukemia

Utilizing single-cell RNA and T cell receptor profiling, researchers showed that irrespective of STAT3 mutation status, T cell large granular lymphocytic leukemia clonotypes were more cytotoxic and exhausted than healthy reactive clonotypes.