The Chemokine CCL1 Triggers an AMFR-SPRY1 Pathway That Promotes Differentiation of Lung Fibroblasts into Myofibroblasts and Drives Pulmonary Fibrosis

Scientists examined the role of CCL1 in pulmonary fibrosis (PF). Bronchoalveolar lavage fluid from PF mouse models contained high amounts of CCL1, as did lung biopsies from PF patients.