β-Catenin-CCL2 Feedback Loop Mediates Crosstalk between Cancer Cells and Macrophages That Regulates Breast Cancer Stem Cells

Macrophages co-cultured with breast cancer cells showed a significant increase in CCL2 expression and promoted β-Catenin-induced breast cancer stem cells (BCSCs) properties, whereas depletion of CCL2 by adding neutralizing antibodies suppressed BSCSs properties.