Intratracheal bleomycin was used to induce acute lung injury in mice, and intratracheal MSCs in a supernatant lyophilized powder was administered as a treatment.
[Stem Cell Research & Therapy]
6445212 {6445212:LFTGL6PG} apa 50 1 160678 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-4b83fb6dbbbab6912f542076cd6723b5%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22LFTGL6PG%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Peng%20et%20al.%22%2C%22parsedDate%22%3A%222021-03-29%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EPeng%2C%20W.%2C%20Chang%2C%20M.%2C%20Wu%2C%20Y.%2C%20Zhu%2C%20W.%2C%20Tong%2C%20L.%2C%20Zhang%2C%20G.%2C%20Wang%2C%20Q.%2C%20Liu%2C%20J.%2C%20Zhu%2C%20X.%2C%20Cheng%2C%20T.%2C%20Li%2C%20Y.%2C%20Chen%2C%20X.%2C%20Weng%2C%20D.%2C%20Liu%2C%20S.%2C%20Zhang%2C%20H.%2C%20Su%2C%20Y.%2C%20Zhou%2C%20J.%2C%20Li%2C%20H.%2C%20%26amp%3B%20Song%2C%20Y.%20%282021%29.%20Lyophilized%20powder%20of%20mesenchymal%20stem%20cell%20supernatant%20attenuates%20acute%20lung%20injury%20through%20the%20IL-6%26%23x2013%3Bp-STAT3%26%23x2013%3Bp63%26%23x2013%3BJAG2%20pathway.%20%3Ci%3EStem%20Cell%20Research%20%26amp%3B%20Therapy%3C%5C%2Fi%3E%2C%20%3Ci%3E12%3C%5C%2Fi%3E%281%29%2C%20216.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13287-021-02276-y%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13287-021-02276-y%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DLFTGL6PG%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Lyophilized%20powder%20of%20mesenchymal%20stem%20cell%20supernatant%20attenuates%20acute%20lung%20injury%20through%20the%20IL-6%5Cu2013p-STAT3%5Cu2013p63%5Cu2013JAG2%20pathway%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wenjun%22%2C%22lastName%22%3A%22Peng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Meijia%22%2C%22lastName%22%3A%22Chang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yuanyuan%22%2C%22lastName%22%3A%22Wu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wensi%22%2C%22lastName%22%3A%22Zhu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lin%22%2C%22lastName%22%3A%22Tong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ge%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qin%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jie%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaoping%22%2C%22lastName%22%3A%22Zhu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tingting%22%2C%22lastName%22%3A%22Cheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yijia%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xi%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dong%22%2C%22lastName%22%3A%22Weng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sanhong%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hongwei%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yao%22%2C%22lastName%22%3A%22Su%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jian%22%2C%22lastName%22%3A%22Zhou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Huayin%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yuanlin%22%2C%22lastName%22%3A%22Song%22%7D%5D%2C%22abstractNote%22%3A%22Acute%20lung%20injury%20%28ALI%29%20and%20acute%20respiratory%20distress%20syndrome%20%28ARDS%29%20are%20syndromes%20of%20acute%20respiratory%20failure%20with%20extremely%20high%20mortality%20and%20few%20effective%20treatments.%20Mesenchymal%20stem%20cells%20%28MSCs%29%20may%20reportedly%20contribute%20to%20tissue%20repair%20in%20ALI%20and%20ARDS.%20However%2C%20applications%20of%20MSCs%20have%20been%20restricted%20due%20to%20safety%20considerations%20and%20limitations%20in%20terms%20of%20large-scale%20production%20and%20industrial%20delivery.%20Alternatively%2C%20the%20MSC%20secretome%20has%20been%20considered%20promising%20for%20use%20in%20therapeutic%20approaches%20and%20has%20been%20advanced%20in%20pre-clinical%20and%20clinical%20trials.%20Furthermore%2C%20the%20MSC%20secretome%20can%20be%20freeze-dried%20into%20a%20stable%20and%20ready-to-use%20supernatant%20lyophilized%20powder%20%28SLP%29%20form.%20Currently%2C%20there%20are%20no%20studies%20on%20the%20role%20of%20MSC%20SLP%20in%20ALI.%22%2C%22date%22%3A%22March%2029%2C%202021%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs13287-021-02276-y%22%2C%22ISSN%22%3A%221757-6512%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13287-021-02276-y%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-03-30T17%3A32%3A35Z%22%7D%7D%5D%7D
Peng, W., Chang, M., Wu, Y., Zhu, W., Tong, L., Zhang, G., Wang, Q., Liu, J., Zhu, X., Cheng, T., Li, Y., Chen, X., Weng, D., Liu, S., Zhang, H., Su, Y., Zhou, J., Li, H., & Song, Y. (2021). Lyophilized powder of mesenchymal stem cell supernatant attenuates acute lung injury through the IL-6–p-STAT3–p63–JAG2 pathway. Stem Cell Research & Therapy, 12(1), 216. https://doi.org/10.1186/s13287-021-02276-y Cite