Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News12 patients with primary or secondary graft failure received T-cell replete bone marrow grafts from haploidentical donors and post-transplantation cyclophosphamide.
[Bone Marrow Transplantation]
6445212 IDW795SW items 1 apa 0 default asc 1 162048 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-5f65f1522307a5869b037b9a80f9bcc0%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22IDW795SW%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Albert%20et%20al.%22%2C%22parsedDate%22%3A%222021-05-09%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EAlbert%2C%20M.%20H.%2C%20Sirin%2C%20M.%2C%20Hoenig%2C%20M.%2C%20Hauck%2C%20F.%2C%20Schuetz%2C%20C.%2C%20Bhattacharyya%2C%20R.%2C%20Stepensky%2C%20P.%2C%20Jacoby%2C%20E.%2C%20G%26%23xFC%3Bng%26%23xF6%3Br%2C%20T.%2C%20Beier%2C%20R.%2C%20%26amp%3B%20Schulz%2C%20A.%20%282021%29.%20Salvage%20HLA-haploidentical%20hematopoietic%20stem%20cell%20transplantation%20with%20post-transplant%20cyclophosphamide%20for%20graft%20failure%20in%20non-malignant%20disorders.%20%3Ci%3EBone%20Marrow%20Transplantation%3C%5C%2Fi%3E%2C%201%26%23x2013%3B11.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41409-021-01323-9%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41409-021-01323-9%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DIDW795SW%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Salvage%20HLA-haploidentical%20hematopoietic%20stem%20cell%20transplantation%20with%20post-transplant%20cyclophosphamide%20for%20graft%20failure%20in%20non-malignant%20disorders%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20H.%22%2C%22lastName%22%3A%22Albert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mehtap%22%2C%22lastName%22%3A%22Sirin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Manfred%22%2C%22lastName%22%3A%22Hoenig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Hauck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catharina%22%2C%22lastName%22%3A%22Schuetz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rajat%22%2C%22lastName%22%3A%22Bhattacharyya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Polina%22%2C%22lastName%22%3A%22Stepensky%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elad%22%2C%22lastName%22%3A%22Jacoby%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tayfun%22%2C%22lastName%22%3A%22G%5Cu00fcng%5Cu00f6r%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rita%22%2C%22lastName%22%3A%22Beier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ansgar%22%2C%22lastName%22%3A%22Schulz%22%7D%5D%2C%22abstractNote%22%3A%22Graft%20failure%20requires%20urgent%20salvage%20HSCT%2C%20but%20there%20is%20no%20universally%20accepted%20approach%20for%20this%20situation.%20We%20investigated%20T-cell%20replete%20haploidentical%20HSCT%20with%20post-transplantation%20cyclophosphamide%20following%20serotherapy-based%2C%20radiation-free%2C%20reduced%20intensity%20conditioning%20in%20children%20with%20non-malignant%20disorders%20who%20had%20rejected%20their%20primary%20graft.%20Twelve%20patients%20with%20primary%20or%20secondary%20graft%20failure%20received%20T-cell%20replete%20bone%20marrow%20grafts%20from%20haploidentical%20donors%20and%20post-transplantation%20cyclophosphamide.%20The%20recommended%20conditioning%20regimen%20comprised%20rituximab%20375%5Cu2009mg%5C%2Fm2%2C%20alemtuzumab%200.4%5Cu2009mg%5C%2Fkg%2C%20fludarabine%20150%5Cu2009mg%5C%2Fm2%2C%20treosulfan%2020%5Cu201324%5Cu2009g%5C%2Fm2%20and%20cyclophosphamide%2029%5Cu2009mg%5C%2Fkg.%20After%20a%20median%20follow-up%20of%2026%20months%20%287%5Cu201395%29%2C%20eleven%20of%20twelve%20patients%20%2892%25%29%20are%20alive%20and%20well%20with%20complete%20donor%20chimerism%20in%20ten.%20Neutrophil%20and%20platelet%20engraftment%20were%20observed%20in%20all%20patients%20after%20a%20median%20of%2018%20days%20%2815%5Cu201361%29%20and%2039%20days%20%2815%5Cu2013191%29%2C%20respectively.%20Acute%20GVHD%20grade%20I%20was%20observed%20in%201%5C%2F12%20patients%20%288%25%29%20and%20mild%20chronic%20GVHD%20in%201%5C%2F12%20patients%20%288%25%29.%20Viral%20reactivations%20and%20disease%20were%20frequent%20complications%20at%2075%25%20and%2042%25%2C%20respectively%2C%20but%20no%20death%20from%20infectious%20causes%20occurred.%20In%20summary%2C%20this%20retrospective%20analysis%20demonstrates%20that%20a%20post-transplantation%20cyclophosphamide-based%20HLA-haploidentical%20salvage%20HSCT%20after%20irradiation-free%20conditioning%20results%20in%20excellent%20engraftment%20and%20overall%20survival%20in%20children%20with%20non-malignant%20diseases.%22%2C%22date%22%3A%222021-05-09%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41409-021-01323-9%22%2C%22ISSN%22%3A%221476-5365%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41409-021-01323-9%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-05-10T17%3A13%3A58Z%22%7D%7D%5D%7D
Albert, M. H., Sirin, M., Hoenig, M., Hauck, F., Schuetz, C., Bhattacharyya, R., Stepensky, P., Jacoby, E., Güngör, T., Beier, R., & Schulz, A. (2021). Salvage HLA-haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide for graft failure in non-malignant disorders. Bone Marrow Transplantation, 1–11. https://doi.org/10.1038/s41409-021-01323-9 Cite
