Blockade of the Co-Inhibitory Molecule PD-1 Unleashes ILC2-Dependent Antitumor Immunity in Melanoma

By
Justin.choi
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Scientists found that high group 2 innate lymphoid cells (ILC2) infiltration in human melanoma was associated with a good clinical prognosis. ILC2s were critical producers of the cytokine granulocyte-macrophage colony-stimulating factor, which coordinated the recruitment and activation of eosinophils to enhance antitumor responses.
[Nature Immunology]
Jacquelot, N., Seillet, C., Wang, M., Pizzolla, A., Liao, Y., Hediyeh-zadeh, S., Grisaru-Tal, S., Louis, C., Huang, Q., Schreuder, J., Souza-Fonseca-Guimaraes, F., de Graaf, C. A., Thia, K., Macdonald, S., Camilleri, M., Luong, K., Zhang, S., Chopin, M., Molden-Hauer, T., … Belz, G. T. (2021). Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma. Nature Immunology, 1–14. https://doi.org/10.1038/s41590-021-00943-z Cite
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