Comparative Analysis of Patient-Matched PDOs Revealed a Reduction in OLFM4-Associated Clusters in Metastatic Lesions in Colorectal Cancer

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Combined bulk transcriptomic and single-cell RNA-sequencing analysis revealed decreased gene expression of markers for differentiated cells in patient-derived organoids derived from metastatic lesions.
[Stem Cell Reports]
Okamoto, T., duVerle, D., Yaginuma, K., Natsume, Y., Yamanaka, H., Kusama, D., Fukuda, M., Yamamoto, M., Perraudeau, F., Srivastava, U., Kashima, Y., Suzuki, A., Kuze, Y., Takahashi, Y., Ueno, M., Sakai, Y., Noda, T., Tsuda, K., Suzuki, Y., … Yao, R. (2021). Comparative Analysis of Patient-Matched PDOs Revealed a Reduction in OLFM4-Associated Clusters in Metastatic Lesions in Colorectal Cancer. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.02.012 Cite
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