Scientists systematically review preclinical studies, explored the effectiveness of mesenchyal stem cells (MSCs) in the treatment of bleomycin-induced pulmonary fibrosis and analyze the potential mechanism, combined with clinical trials of current MSCs for idiopathic pulmonary fibrosis and COVID-19, so as to provide support for clinical research and transformation of MSCs.
[Stem Cell Research & Therapy]
6445212 HEQPFFAC items 1 apa 0 default asc 1 166031 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-2153cb39ae191cb08b076e48ce400011%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22HEQPFFAC%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zhao%20et%20al.%22%2C%22parsedDate%22%3A%222021-08-23%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EZhao%2C%20Y.%2C%20Yan%2C%20Z.%2C%20Liu%2C%20Y.%2C%20Zhang%2C%20Y.%2C%20Shi%2C%20J.%2C%20Li%2C%20J.%2C%20%26amp%3B%20Ji%2C%20F.%20%282021%29.%20Effectivity%20of%20mesenchymal%20stem%20cells%20for%20bleomycin-induced%20pulmonary%20fibrosis%3A%20a%20systematic%20review%20and%20implication%20for%20clinical%20application.%20%3Ci%3EStem%20Cell%20Research%20%26amp%3B%20Therapy%3C%5C%2Fi%3E%2C%20%3Ci%3E12%3C%5C%2Fi%3E%281%29%2C%20470.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13287-021-02551-y%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13287-021-02551-y%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DHEQPFFAC%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Effectivity%20of%20mesenchymal%20stem%20cells%20for%20bleomycin-induced%20pulmonary%20fibrosis%3A%20a%20systematic%20review%20and%20implication%20for%20clinical%20application%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yunyu%22%2C%22lastName%22%3A%22Zhao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhipeng%22%2C%22lastName%22%3A%22Yan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ying%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yue%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jie%22%2C%22lastName%22%3A%22Shi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jingtao%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fanpu%22%2C%22lastName%22%3A%22Ji%22%7D%5D%2C%22abstractNote%22%3A%22Pulmonary%20fibrosis%20%28PF%29%20is%20a%20chronic%2C%20progressive%2C%20fibrotic%20interstitial%20disease%20of%20the%20lung%20with%20poor%20prognosis%20and%20without%20effective%20treatment%20currently.%20Data%20from%20previous%20coronavirus%20infections%2C%20such%20as%20the%20Severe%20Acute%20Respiratory%20Syndrome%20%28SARS%29%20and%20Middle%20East%20Respiratory%20Syndrome%2C%20as%20well%20as%20current%20clinical%20evidence%20from%20the%20Coronavirus%20disease%202019%20%28COVID-19%29%2C%20support%20that%20SARS-CoV-2%20infection%20may%20lead%20to%20PF%2C%20seriously%20impacting%20patient%20prognosis%20and%20quality%20of%20life.%20Therefore%2C%20effective%20prevention%20and%20treatment%20of%20PF%20will%20improve%20patient%20prognosis%20and%20reduce%20the%20overall%20social%20and%20economic%20burdens.%20Stem%20cells%2C%20especially%20mesenchymal%20stem%20cells%20%28MSCs%29%20have%20many%20great%20advantages%2C%20including%20migration%20to%20damaged%20lung%20tissue%20and%20secretion%20of%20various%20paracrine%20factors%2C%20thereby%20regulating%20the%20permeability%20of%20endothelial%20and%20epithelial%20cells%2C%20reducing%20inflammatory%20response%2C%20promoting%20tissue%20repair%20and%20inhibiting%20bacterial%20growth.%20Clinical%20trials%20of%20MSCs%20for%20the%20treatment%20of%20acute%20lung%20injury%2C%20PF%20and%20severe%20and%20critically%20ill%20COVID-19%20are%20ongoing.%20The%20purpose%20of%20this%20study%20is%20to%20systematically%20review%20preclinical%20studies%2C%20explored%20the%20effectiveness%20of%20MSCs%20in%20the%20treatment%20of%20bleomycin%20%28BLM%29-induced%20pulmonary%20fibrosis%20and%20analyze%20the%20potential%20mechanism%2C%20combined%20with%20clinical%20trials%20of%20current%20MSCs%20for%20idiopathic%5Cu00a0pulmonary%5Cu00a0fibrosis%20%28IPF%29%20and%20COVID-19%2C%20so%20as%20to%20provide%20support%20for%20clinical%20research%20and%20transformation%20of%20MSCs.%20Searching%20PubMed%20and%20Embase%20%28%5Cu2212%5Cu00a02021.4%29%20identified%20a%20total%20of%2036%20preclinical%20studies%20of%20MSCs%20as%20treatment%20of%20BLM-induced%20acute%20lung%20injury%20and%20PF%20in%20rodent%20models.%20Most%20of%20the%20studies%20showed%20the%20MSCs%20treatment%20to%20reduce%20BLM-induced%20lung%20tissue%20inflammatory%20response%2C%20inflammatory%20cell%20infiltration%2C%20inflammatory%20cytokine%20expression%2C%20extracellular%20matrix%20production%20and%20collagen%20deposition%2C%20and%20to%20improve%20Ashcroft%20score.%20The%20results%20of%20present%20studies%20indicate%20that%20MSCs%20may%20serve%20as%20a%20potential%20therapeutic%20modality%20for%20the%20treatment%20of%20PF%2C%20including%20viral-induced%20PF%20and%20IPF.%22%2C%22date%22%3A%22August%2023%2C%202021%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs13287-021-02551-y%22%2C%22ISSN%22%3A%221757-6512%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13287-021-02551-y%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-08-24T20%3A46%3A27Z%22%7D%7D%5D%7D
Zhao, Y., Yan, Z., Liu, Y., Zhang, Y., Shi, J., Li, J., & Ji, F. (2021). Effectivity of mesenchymal stem cells for bleomycin-induced pulmonary fibrosis: a systematic review and implication for clinical application. Stem Cell Research & Therapy, 12(1), 470. https://doi.org/10.1186/s13287-021-02551-y Cite