Multilineage Murine Stem Cells Generate Complex Organoids to Model Distal Lung Development and Disease

0
58
The authors established a three‐dimensional murine bronchioalveolar lung organoid model that allows clonal expansion and self‐organization of FACS‐sorted bronchioalveolar stem cells upon co‐culture with lung‐resident mesenchymal cells.
[EMBO Journal]
1254621 {1254621:TCAT985Y} 1 apa 50 default 1 154723 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22TCAT985Y%22%2C%22library%22%3A%7B%22id%22%3A1254621%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Vazquez-Armendariz%20et%20al.%22%2C%22parsedDate%22%3A%222020-09-28%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BVazquez-Armendariz%2C%20A.%20I.%2C%20Heiner%2C%20M.%2C%20El%20Agha%2C%20E.%2C%20Salwig%2C%20I.%2C%20Hoek%2C%20A.%2C%20Hessler%2C%20M.%20C.%2C%20Shalashova%2C%20I.%2C%20Shrestha%2C%20A.%2C%20Carraro%2C%20G.%2C%20Mengel%2C%20J.%20P.%2C%20G%26%23xFC%3Bnther%2C%20A.%2C%20Morty%2C%20R.%20E.%2C%20Vad%26%23xE1%3Bsz%2C%20I.%2C%20Schwemmle%2C%20M.%2C%20Kummer%2C%20W.%2C%20Hain%2C%20T.%2C%20Goesmann%2C%20A.%2C%20Bellusci%2C%20S.%2C%20Seeger%2C%20W.%2C%20%26%23x2026%3B%20Herold%2C%20S.%20%282020%29.%20Multilineage%20murine%20stem%20cells%20generate%20complex%20organoids%20to%20model%20distal%20lung%20development%20and%20disease.%20%26lt%3Bi%26gt%3BThe%20EMBO%20Journal%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3Bn%5C%2Fa%26lt%3B%5C%2Fi%26gt%3B%28n%5C%2Fa%29%2C%20e103476.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.15252%5C%2Fembj.2019103476%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.15252%5C%2Fembj.2019103476%26lt%3B%5C%2Fa%26gt%3B%20%26lt%3Ba%20title%3D%26%23039%3BCite%20in%20RIS%20Format%26%23039%3B%20class%3D%26%23039%3Bzp-CiteRIS%26%23039%3B%20data-zp-cite%3D%26%23039%3Bapi_user_id%3D1254621%26amp%3Bitem_key%3DTCAT985Y%26%23039%3B%20href%3D%26%23039%3Bjavascript%3Avoid%280%29%3B%26%23039%3B%26gt%3BCite%26lt%3B%5C%2Fa%26gt%3B%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Multilineage%20murine%20stem%20cells%20generate%20complex%20organoids%20to%20model%20distal%20lung%20development%20and%20disease%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ana%20Ivonne%22%2C%22lastName%22%3A%22Vazquez-Armendariz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monika%22%2C%22lastName%22%3A%22Heiner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elie%22%2C%22lastName%22%3A%22El%20Agha%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Salwig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Hoek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%20Christin%22%2C%22lastName%22%3A%22Hessler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Irina%22%2C%22lastName%22%3A%22Shalashova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amit%22%2C%22lastName%22%3A%22Shrestha%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gianni%22%2C%22lastName%22%3A%22Carraro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%20Philip%22%2C%22lastName%22%3A%22Mengel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rory%20Edward%22%2C%22lastName%22%3A%22Morty%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Istv%5Cu00e1n%22%2C%22lastName%22%3A%22Vad%5Cu00e1sz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%22%2C%22lastName%22%3A%22Schwemmle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Kummer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Torsten%22%2C%22lastName%22%3A%22Hain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Goesmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Saverio%22%2C%22lastName%22%3A%22Bellusci%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Werner%22%2C%22lastName%22%3A%22Seeger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Braun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susanne%22%2C%22lastName%22%3A%22Herold%22%7D%5D%2C%22abstractNote%22%3A%22%5Cu4162%5Cu7374%5Cu7261%5Cu6374%5Cu204f%5Cu7267%5Cu616e%5Cu6f69%5Cu6473%5Cu2064%5Cu6572%5Cu6976%5Cu6564%5Cu2066%5Cu726f%5Cu6d20%5Cu6d6f%5Cu7573%5Cu6520%5Cu616e%5Cu6420%5Cu6875%5Cu6d61%5Cu6e20%5Cu7374%5Cu656d%5Cu2063%5Cu656c%5Cu6c73%5Cu2068%5Cu6176%5Cu6520%5Cu7265%5Cu6365%5Cu6e74%5Cu6c79%5Cu2065%5Cu6d65%5Cu7267%5Cu6564%5Cu2061%5Cu7320%5Cu6120%5Cu706f%5Cu7765%5Cu7266%5Cu756c%5Cu2074%5Cu6f6f%5Cu6c20%5Cu746f%5Cu2073%5Cu7475%5Cu6479%5Cu206f%5Cu7267%5Cu616e%5Cu2064%5Cu6576%5Cu656c%5Cu6f70%5Cu6d65%5Cu6e74%5Cu2061%5Cu6e64%5Cu2064%5Cu6973%5Cu6561%5Cu7365%5Cu2e20%5Cu5765%5Cu2068%5Cu6572%5Cu6520%5Cu6573%5Cu7461%5Cu626c%5Cu6973%5Cu6865%5Cu6420%5Cu6120%5Cu7468%5Cu7265%5Cu652d%5Cu6469%5Cu6d65%5Cu6e73%5Cu696f%5Cu6e61%5Cu6c20%5Cu2833%5Cu4429%5Cu206d%5Cu7572%5Cu696e%5Cu6520%5Cu6272%5Cu6f6e%5Cu6368%5Cu696f%5Cu616c%5Cu7665%5Cu6f6c%5Cu6172%5Cu206c%5Cu756e%5Cu6720%5Cu6f72%5Cu6761%5Cu6e6f%5Cu6964%5Cu2028%5Cu4241%5Cu4c4f%5Cu2920%5Cu6d6f%5Cu6465%5Cu6c20%5Cu7468%5Cu6174%5Cu2061%5Cu6c6c%5Cu6f77%5Cu7320%5Cu636c%5Cu6f6e%5Cu616c%5Cu2065%5Cu7870%5Cu616e%5Cu7369%5Cu6f6e%5Cu2061%5Cu6e64%5Cu2073%5Cu656c%5Cu662d%5Cu6f72%5Cu6761%5Cu6e69%5Cu7a61%5Cu7469%5Cu6f6e%5Cu206f%5Cu6620%5Cu4641%5Cu4353%5Cu2d73%5Cu6f72%5Cu7465%5Cu6420%5Cu6272%5Cu6f6e%5Cu6368%5Cu696f%5Cu616c%5Cu7665%5Cu6f6c%5Cu6172%5Cu2073%5Cu7465%5Cu6d20%5Cu6365%5Cu6c6c%5Cu7320%5Cu2842%5Cu4153%5Cu4373%5Cu2920%5Cu7570%5Cu6f6e%5Cu2063%5Cu6f2d%5Cu6375%5Cu6c74%5Cu7572%5Cu6520%5Cu7769%5Cu7468%5Cu206c%5Cu756e%5Cu672d%5Cu7265%5Cu7369%5Cu6465%5Cu6e74%5Cu206d%5Cu6573%5Cu656e%5Cu6368%5Cu796d%5Cu616c%5Cu2063%5Cu656c%5Cu6c73%5Cu2e20%5Cu4241%5Cu4c4f%5Cu7320%5Cu7969%5Cu656c%5Cu6420%5Cu6120%5Cu6869%5Cu6768%5Cu6c79%5Cu2062%5Cu7261%5Cu6e63%5Cu6865%5Cu6420%5Cu3344%5Cu2073%5Cu7472%5Cu7563%5Cu7475%5Cu7265%5Cu2077%5Cu6974%5Cu6869%5Cu6e20%5Cu3231%5Cuc2a0%5Cu6461%5Cu7973%5Cu206f%5Cu6620%5Cu6375%5Cu6c74%5Cu7572%5Cu652c%5Cu206d%5Cu696d%5Cu6963%5Cu6b69%5Cu6e67%5Cu2074%5Cu6865%5Cu2063%5Cu656c%5Cu6c75%5Cu6c61%5Cu7220%5Cu636f%5Cu6d70%5Cu6f73%5Cu6974%5Cu696f%5Cu6e20%5Cu6f66%5Cu2074%5Cu6865%5Cu2062%5Cu726f%5Cu6e63%5Cu6869%5Cu6f61%5Cu6c76%5Cu656f%5Cu6c61%5Cu7220%5Cu636f%5Cu6d70%5Cu6172%5Cu746d%5Cu656e%5Cu7420%5Cu6173%5Cu2064%5Cu6566%5Cu696e%5Cu6564%5Cu2062%5Cu7920%5Cu7369%5Cu6e67%5Cu6c65%5Cu2d63%5Cu656c%5Cu6c20%5Cu524e%5Cu4120%5Cu7365%5Cu7175%5Cu656e%5Cu6369%5Cu6e67%5Cu2061%5Cu6e64%5Cu2066%5Cu6c75%5Cu6f72%5Cu6573%5Cu6365%5Cu6e63%5Cu6520%5Cu6173%5Cu2077%5Cu656c%5Cu6c20%5Cu6173%5Cu2065%5Cu6c65%5Cu6374%5Cu726f%5Cu6e20%5Cu6d69%5Cu6372%5Cu6f73%5Cu636f%5Cu7069%5Cu6320%5Cu7068%5Cu656e%5Cu6f74%5Cu7970%5Cu696e%5Cu672e%5Cu2041%5Cu6464%5Cu6974%5Cu696f%5Cu6e61%5Cu6c6c%5Cu792c%5Cu2042%5Cu414c%5Cu4f73%5Cu2073%5Cu7570%5Cu706f%5Cu7274%5Cu2065%5Cu6e67%5Cu7261%5Cu6674%5Cu6d65%5Cu6e74%5Cu2061%5Cu6e64%5Cu206d%5Cu6169%5Cu6e74%5Cu656e%5Cu616e%5Cu6365%5Cu206f%5Cu6620%5Cu7468%5Cu6520%5Cu6365%5Cu6c6c%5Cu756c%5Cu6172%5Cu2070%5Cu6865%5Cu6e6f%5Cu7479%5Cu7065%5Cu206f%5Cu6620%5Cu696e%5Cu6a65%5Cu6374%5Cu6564%5Cu2074%5Cu6973%5Cu7375%5Cu652d%5Cu7265%5Cu7369%5Cu6465%5Cu6e74%5Cu206d%5Cu6163%5Cu726f%5Cu7068%5Cu6167%5Cu6573%5Cu2e20%5Cu5765%5Cu2061%5Cu6c73%5Cu6f20%5Cu6465%5Cu6d6f%5Cu6e73%5Cu7472%5Cu6174%5Cu6520%5Cu7468%5Cu6174%5Cu2042%5Cu414c%5Cu4f73%5Cu2072%5Cu6563%5Cu6170%5Cu6974%5Cu756c%5Cu6174%5Cu6520%5Cu6c75%5Cu6e67%5Cu2064%5Cu6576%5Cu656c%5Cu6f70%5Cu6d65%5Cu6e74%5Cu616c%5Cu2064%5Cu6566%5Cu6563%5Cu7473%5Cu2061%5Cu6674%5Cu6572%5Cu206b%5Cu6e6f%5Cu636b%5Cu646f%5Cu776e%5Cu206f%5Cu6620%5Cu6120%5Cu6372%5Cu6974%5Cu6963%5Cu616c%5Cu2072%5Cu6567%5Cu756c%5Cu6174%5Cu6f72%5Cu7920%5Cu6765%5Cu6e65%5Cu2c20%5Cu616e%5Cu6420%5Cu7065%5Cu726d%5Cu6974%5Cu206d%5Cu6f64%5Cu656c%5Cu696e%5Cu6720%5Cu6f66%5Cu2076%5Cu6972%5Cu616c%5Cu2069%5Cu6e66%5Cu6563%5Cu7469%5Cu6f6e%5Cu2e20%5Cu5765%5Cu2063%5Cu6f6e%5Cu636c%5Cu7564%5Cu6520%5Cu7468%5Cu6174%5Cu2074%5Cu6865%5Cu2042%5Cu414c%5Cu4f20%5Cu6d6f%5Cu6465%5Cu6c20%5Cu656e%5Cu6162%5Cu6c65%5Cu7320%5Cu7265%5Cu636f%5Cu6e73%5Cu7472%5Cu7563%5Cu7469%5Cu6f6e%5Cu206f%5Cu6620%5Cu7468%5Cu6520%5Cu6570%5Cu6974%5Cu6865%5Cu6c69%5Cu616c%5Cu3f6d%5Cu6573%5Cu656e%5Cu6368%5Cu796d%5Cu616c%5Cu2d6d%5Cu7965%5Cu6c6f%5Cu6964%5Cu2075%5Cu6e69%5Cu7420%5Cu6f66%5Cu2074%5Cu6865%5Cu2064%5Cu6973%5Cu7461%5Cu6c20%5Cu6c75%5Cu6e67%5Cu2c20%5Cu7468%5Cu6572%5Cu6562%5Cu7920%5Cu6f70%5Cu656e%5Cu696e%5Cu6720%5Cu6e75%5Cu6d65%5Cu726f%5Cu7573%5Cu206e%5Cu6577%5Cu2061%5Cu7665%5Cu6e75%5Cu6573%5Cu2074%5Cu6f20%5Cu7374%5Cu7564%5Cu7920%5Cu6c75%5Cu6e67%5Cu2064%5Cu6576%5Cu656c%5Cu6f70%5Cu6d65%5Cu6e74%5Cu2c20%5Cu696e%5Cu6665%5Cu6374%5Cu696f%5Cu6e2c%5Cu2061%5Cu6e64%5Cu2072%5Cu6567%5Cu656e%5Cu6572%5Cu6174%5Cu6976%5Cu6520%5Cu7072%5Cu6f63%5Cu6573%5Cu7365%5Cu7320%5Cu696e%5Cuc2a0%5Cu7669%5Cu7472%5Cu6f2e%22%2C%22date%22%3A%22September%2028%2C%202020%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.15252%5C%2Fembj.2019103476%22%2C%22ISSN%22%3A%220261-4189%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.embopress.org%5C%2Fdoi%5C%2Ffull%5C%2F10.15252%5C%2Fembj.2019103476%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222020-09-30T18%3A17%3A02Z%22%7D%7D%5D%7D
Vazquez-Armendariz, A. I., Heiner, M., El Agha, E., Salwig, I., Hoek, A., Hessler, M. C., Shalashova, I., Shrestha, A., Carraro, G., Mengel, J. P., Günther, A., Morty, R. E., Vadász, I., Schwemmle, M., Kummer, W., Hain, T., Goesmann, A., Bellusci, S., Seeger, W., … Herold, S. (2020). Multilineage murine stem cells generate complex organoids to model distal lung development and disease. The EMBO Journal, n/a(n/a), e103476. https://doi.org/10.15252/embj.2019103476 Cite
AbstractGraphical Abstract