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Pulmonary Cell NewsThe authors generated a rat xenotransplantation model to prove the role of macrophages as a xenotransplantation barrier. Immunodeficiency in SRG rats, which were Sprague–Dawley rats lacking Rag2 and Il2rg, was confirmed by flow cytometry and spleen immunostaining.
[Xenotransplantation]
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Furuya, K., Zheng, Y.-W., Ge, J.-Y., Zhang, L., Furuta, T., Liang, C., Abe, H., Yagi, H., Hamada, H., Isoda, H., Hui, L., Ohkohchi, N., & Oda, T. (n.d.). The evidence of a macrophage barrier in the xenotransplantation of human hematopoietic stem cells to severely immunodeficient rats. Xenotransplantation, n/a(n/a), e12702. https://doi.org/10.1111/xen.12702 Cite
