dendritic cells

[Genes & Diseases] With a predicted peptide library from SARS-CoV-2 S and N proteins, restricted to three of the most prominent HLA-A alleles in the Asian population, investigators found that specific CD8+ T cell responses were identified in over 75% of COVID-19 convalescent patients

[Science Translational Medicine] To specifically trigger sufficient antitumor reactivity without notable adverse effects, scientists developed an antigen and adjuvant codelivery nanoparticle vaccine based on Escherichia coli cytoplasmic membranes (EMs) and tumor cell membranes (TMs) from resected autologous tumor tissue.

[Nature Biomedical Engineering] Scientists reported injectable biomaterial vaccines that triggered potent humoral and T-cell responses to bacterial antigens by recruiting, reprogramming and releasing dendritic cells.

[Nature Communications] Researchers reported that monocyte chemotactic protein-induced protein 3, promoted skin inflammation by simultaneously enhancing tumor necrosis factor in macrophages and repressing interleukin-6 in plasmacytoid dendritic cells.

[Journal of Clinical Investigation] Mechanistically, scientists demonstrated that NK cell degranulation is mediated by binding of the Fc segment of anti-RhD antibodies to CD16, the main Fcγ receptor expressed on NK cells.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers demonstrate that lumican, an ECM protein normally associated with collagens, was elevated in sepsis patients’ blood, while lumican-null mice resolved polymicrobial sepsis poorly, with reduced bacterial clearance and greater body weight loss.