IGF-1R Inhibition Induces MEK Phosphorylation to Promote Survival in Colon Carcinomas

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Justin.choi
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Scientists discovered that prolonged treatment of colon cancer cells with insulin-like growth factor 1 receptor (IGF-1R) inhibitors stimulated p70 KDa ribosomal protein S6 kinase 1 (p70S6K1) activation, a well-known kinase signaling for cell survival. They also found that p70S6K1 activation by IGF-1R inhibition was independent of K-Ras and PIK3CA mutations that frequently occur in colon cancer.
[Signal Transduction and Targeted Therapy]
Wang, Q., Zhang, Y., Zhu, J., Zheng, H., Chen, S., Chen, L., & Yang, H.-S. (2020). IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas. Signal Transduction and Targeted Therapy, 5(1), 1–11. https://doi.org/10.1038/s41392-020-0204-0 Cite
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