Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsScientists analyze four major signaling pathways implicated in melanomagenesis, TGF-β, MAPK, Wnt/β-catenin and Hyppo signaling, from the complementary point of view of tumor cells and the microenvironment.
[Cancers]
6807162 {6807162:A37S827L} apa 50 1 156442 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-fdfad483418d0744108c5d0cd0b30d6d%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22A37S827L%22%2C%22library%22%3A%7B%22id%22%3A6807162%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bellei%20et%20al.%22%2C%22parsedDate%22%3A%222020-11%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EBellei%2C%20B.%2C%20Migliano%2C%20E.%2C%20%26amp%3B%20Picardo%2C%20M.%20%282020%29.%20A%20Framework%20of%20Major%20Tumor-Promoting%20Signal%20Transduction%20Pathways%20Implicated%20in%20Melanoma-Fibroblast%20Dialogue.%20%3Ci%3ECancers%3C%5C%2Fi%3E%2C%20%3Ci%3E12%3C%5C%2Fi%3E%2811%29%2C%203400.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fcancers12113400%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fcancers12113400%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6807162%26amp%3Bitem_key%3DA37S827L%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20Framework%20of%20Major%20Tumor-Promoting%20Signal%20Transduction%20Pathways%20Implicated%20in%20Melanoma-Fibroblast%20Dialogue%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Bellei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emilia%22%2C%22lastName%22%3A%22Migliano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mauro%22%2C%22lastName%22%3A%22Picardo%22%7D%5D%2C%22abstractNote%22%3A%22The%20development%20of%20a%20modified%20stromal%20microenvironment%20in%20response%20to%20neoplastic%20onset%20is%20a%20common%20feature%20of%20many%20tumors%20including%20cutaneous%20melanoma.%20At%20all%20stages%2C%20melanoma%20cells%20are%20embedded%20in%20a%20complex%20tissue%20composed%20by%20extracellular%20matrix%20components%20and%20several%20different%20cell%20populations.%20Thus%2C%20melanomagenesis%20is%20not%20only%20driven%20by%20malignant%20melanocytes%2C%20but%20also%20by%20the%20altered%20communication%20between%20melanocytes%20and%20non-malignant%20cell%20populations%2C%20including%20fibroblasts%2C%20endothelial%20and%20immune%20cells.%20In%20particular%2C%20cancer-associated%20fibroblasts%20%28CAFs%29%2C%20also%20referred%20as%20melanoma-associated%20fibroblasts%20%28MAFs%29%20in%20the%20case%20of%20melanoma%2C%20are%20the%20most%20abundant%20stromal%20cells%20and%20play%20a%20significant%20contextual%20role%20in%20melanoma%20initiation%2C%20progression%20and%20metastasis.%20As%20a%20result%20of%20dynamic%20intercellular%20molecular%20dialogue%20between%20tumor%20and%20the%20stroma%2C%20non-neoplastic%20cells%20gain%20specific%20phenotypes%20and%20functions%20that%20are%20pro-tumorigenic.%20Targeting%20MAFs%20is%20thus%20considered%20a%20promising%20avenue%20to%20improve%20melanoma%20therapy.%20Growing%20evidence%20demonstrates%20that%20aberrant%20regulation%20of%20oncogenic%20signaling%20is%20not%20restricted%20to%20transformed%20cells%20but%20also%20occurs%20in%20MAFs.%20However%2C%20in%20some%20cases%2C%20signaling%20pathways%20present%20opposite%20regulation%20in%20melanoma%20and%20surrounding%20area%2C%20suggesting%20that%20therapeutic%20strategies%20need%20to%20carefully%20consider%20the%20tumor%26ndash%3Bstroma%20equilibrium.%20In%20this%20novel%20review%2C%20we%20analyze%20four%20major%20signaling%20pathways%20implicated%20in%20melanomagenesis%2C%20TGF-%26beta%3B%2C%20MAPK%2C%20Wnt%5C%2F%26beta%3B-catenin%20and%20Hyppo%20signaling%2C%20from%20the%20complementary%20point%20of%20view%20of%20tumor%20cells%20and%20the%20microenvironment.%22%2C%22date%22%3A%222020%5C%2F11%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.3390%5C%2Fcancers12113400%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.mdpi.com%5C%2F2072-6694%5C%2F12%5C%2F11%5C%2F3400%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222020-11-20T21%3A02%3A47Z%22%7D%7D%5D%7D
Bellei, B., Migliano, E., & Picardo, M. (2020). A Framework of Major Tumor-Promoting Signal Transduction Pathways Implicated in Melanoma-Fibroblast Dialogue. Cancers, 12(11), 3400. https://doi.org/10.3390/cancers12113400 Cite
