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Pulmonary Cell NewsResearchers investigated the effects of Bruton’s tyrosine kinase (BTK) on oncurrent chemoradiotherapy-resistant oral squamous cell carcinoma tissues (OSCC). The effect of ibrutinib, a first-in-class BTK inhibitor, was tested on stem cell-like OSCC tumorspheres.
[Oncogenesis]
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Liu, S.-C., Wu, Y.-C., Huang, C.-M., Hsieh, M.-S., Huang, T.-Y., Huang, C.-S., Hsu, T.-N., Huang, M.-S., Lee, W.-H., Yeh, C.-T., & Lin, C.-S. (2021). Inhibition of Bruton’s tyrosine kinase as a therapeutic strategy for chemoresistant oral squamous cell carcinoma and potential suppression of cancer stemness. Oncogenesis, 10(2), 1–18. https://doi.org/10.1038/s41389-021-00308-z Cite
