Scientists showed that adoptive transfer of regulatory T (Treg) cells largely reversed maternal immune activation-induced phenotypes.
[Nature Neuroscience]
6445218 {6445218:NHUHM7QI} apa 50 1 161268 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-99568be253d525c40a3f216fd680c3aa%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22NHUHM7QI%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Xu%20et%20al.%22%2C%22parsedDate%22%3A%222021-04-15%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EXu%2C%20Z.%2C%20Zhang%2C%20X.%2C%20Chang%2C%20H.%2C%20Kong%2C%20Y.%2C%20Ni%2C%20Y.%2C%20Liu%2C%20R.%2C%20Zhang%2C%20X.%2C%20Hu%2C%20Y.%2C%20Yang%2C%20Z.%2C%20Hou%2C%20M.%2C%20Mao%2C%20R.%2C%20Liu%2C%20W.-T.%2C%20Du%2C%20Y.%2C%20Yu%2C%20S.%2C%20Wang%2C%20Z.%2C%20Ji%2C%20M.%2C%20%26amp%3B%20Zhou%2C%20Z.%20%282021%29.%20Rescue%20of%20maternal%20immune%20activation-induced%20behavioral%20abnormalities%20in%20adult%20mouse%20offspring%20by%20pathogen-activated%20maternal%20T%20reg%20cells.%20%3Ci%3ENature%20Neuroscience%3C%5C%2Fi%3E%2C%201%26%23x2013%3B13.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41593-021-00837-1%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41593-021-00837-1%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DNHUHM7QI%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Rescue%20of%20maternal%20immune%20activation-induced%20behavioral%20abnormalities%20in%20adult%20mouse%20offspring%20by%20pathogen-activated%20maternal%20T%20reg%20cells%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhipeng%22%2C%22lastName%22%3A%22Xu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaoyun%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hao%22%2C%22lastName%22%3A%22Chang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yue%22%2C%22lastName%22%3A%22Kong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yangyue%22%2C%22lastName%22%3A%22Ni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ran%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaolin%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yang%22%2C%22lastName%22%3A%22Hu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhi%22%2C%22lastName%22%3A%22Yang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Min%22%2C%22lastName%22%3A%22Hou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rui%22%2C%22lastName%22%3A%22Mao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wen-Tao%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yasong%22%2C%22lastName%22%3A%22Du%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shunying%22%2C%22lastName%22%3A%22Yu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhen%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Minjun%22%2C%22lastName%22%3A%22Ji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zikai%22%2C%22lastName%22%3A%22Zhou%22%7D%5D%2C%22abstractNote%22%3A%22Maternal%20immune%20activation%20%28MIA%29%20induced%20by%20lipopolysaccharides%20or%20polyinosinic%3Apolycytidylic%20acid%20injections%20can%20induce%20behavioral%20abnormalities%20in%20adult%20mouse%20offspring.%20Here%2C%20we%20used%20the%20soluble%20tachyzoite%20antigen%20from%20Toxoplasma%20gondii%2C%20a%20parasite%20that%20infects%20approximately%20two%20billion%20people%2C%20to%20induce%20MIA%20in%20mice.%20The%20adult%20male%20offspring%20showed%20autism-relevant%20behaviors%20and%20abnormal%20brain%20microstructure%2C%20along%20with%20a%20pro-inflammatory%20T-cell%20immune%20profile%20in%20the%20periphery%20and%20upregulation%20of%20interleukin-6%20in%20brain%20astrocytes.%20We%20show%20that%20adoptive%20transfer%20of%20regulatory%20T%20%28Treg%29%20cells%20largely%20reversed%20these%20MIA-induced%20phenotypes.%20Notably%2C%20pathogen-activated%20maternal%20Treg%20cells%20showed%20greater%20rescue%20efficacy%20than%20those%20from%20control%20donors.%20Single-cell%20RNA%20sequencing%20identified%20and%20characterized%20a%20unique%20group%20of%20pathogen-activated%20Treg%20cells%20that%20constitute%2032.6%25%20of%20the%20pathogen-activated%20maternal%20Treg%20population.%20Our%20study%20establishes%20a%20new%20preclinical%20parasite-mimicking%20MIA%20model%20and%20suggests%20therapeutic%20potential%20of%20adoptive%20Treg%20cell%20transfer%20in%20neuropsychiatric%20disorders%20associated%20with%20immune%20alterations.%22%2C%22date%22%3A%222021-04-15%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41593-021-00837-1%22%2C%22ISSN%22%3A%221546-1726%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41593-021-00837-1%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-04-16T07%3A03%3A47Z%22%7D%7D%5D%7D
Xu, Z., Zhang, X., Chang, H., Kong, Y., Ni, Y., Liu, R., Zhang, X., Hu, Y., Yang, Z., Hou, M., Mao, R., Liu, W.-T., Du, Y., Yu, S., Wang, Z., Ji, M., & Zhou, Z. (2021). Rescue of maternal immune activation-induced behavioral abnormalities in adult mouse offspring by pathogen-activated maternal T reg cells. Nature Neuroscience, 1–13. https://doi.org/10.1038/s41593-021-00837-1 Cite