By implementing pharmacogenomics and a cell-based drug screen, scientists found that THZ531 led to inhibition of oncogenic transcriptional programs, especially the DNA damage response pathway, MYC target genes and the mTOR-4EBP1-MCL-1 axis, contributing to dramatic lymphoma suppression in vitro.
[Haematologica]
7992332
{7992332:WDPPBB64}
apa
50
1
163930
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