CD47-Targeted Cancer Immunogene Therapy: Secreted SIRPα-FC Fusion Protein Eradicates Tumors by Macrophage and NK Cell Activation

Researchers developed a plasmid-vector encoding for the secreted fusion protein sCV1-hIgG1, comprising of highly efficient CD47-blocking moiety CV1 and Fc domain of human IgG1 with maximized immune activation.