A Novel Cytokine Consisting of the p40 and EBI3 Subunits Suppresses Experimental Autoimmune Arthritis via Reciprocal Regulation of Th17 and Treg Cells

The presence of the p40-EBI3 heterodimer was confirmed by ELISA, immunoprecipitation, and western blotting. A p40-EBI3 vector and p40-EBI3-Fc protein were synthesized to confirm the immunological role of this protein in mice with collagen-induced arthritis