Ablation of Cbl-B and C-cbl in Dendritic Cells Causes Spontaneous Liver Cirrhosis via Altering Multiple Properties of CD103+ cDC1s

Scientists found that specific deletion of Cbl-b and c-Cbl in CD11c+ cells, predominantly in dendritic cells (DCs), led to liver fibrosis, cirrhosis, and accumulation of systemic conventional Type I DCs due to enhanced cell proliferation and decreased cell apoptosis.