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Pulmonary Cell NewsResearchers reported the generation of hypoimmunogenic cancer-antigen-specific T cells derived from induced pluripotent stem cells lacking β2-microglobulin, the class-II major histocompatibility complex transactivator and the natural killer cell-ligand poliovirus receptor CD155, and expressing single-chain MHC class-I antigen E.
[Nature Biomedical Engineering]
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Wang, B., Iriguchi, S., Waseda, M., Ueda, N., Ueda, T., Xu, H., Minagawa, A., Ishikawa, A., Yano, H., Ishi, T., Ito, R., Goto, M., Takahashi, R., Uemura, Y., Hotta, A., & Kaneko, S. (2021). Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells. Nature Biomedical Engineering, 5(5), 429–440. https://doi.org/10.1038/s41551-021-00730-z Cite
