Patients with high-risk DCIS were enrolled in this 3×3 Phase I dose-escalation pilot study of two, four and eight mg intralesional injections of the PD-1 immune checkpoint inhibitor, pembrolizumab.
[npj Breast Cancer]
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Glencer, A. C., Wong, J. M., Hylton, N. M., Krings, G., McCune, E., Rothschild, H. T., Loveday, T. A., Alvarado, M. D., Esserman, L. J., & Campbell, M. J. (2021). Modulation of the immune microenvironment of high-risk ductal carcinoma in situ by intralesional pembrolizumab injection. Npj Breast Cancer, 7(1), 1–10. https://doi.org/10.1038/s41523-021-00267-z Cite