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Pulmonary Cell NewsGlioblastoma-associated microglia/macrophages secreted interleukin 11 activated STAT3-MYC signaling in glioblastoma cells. This signaling induced stem cell states that conferred enhanced tumorigenicity and resistance to the standard-of-care chemotherapy, temozolomide.
[Proceedings of the National Academy of Sciences of the United States of America]
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Li, J., Kaneda, M. M., Ma, J., Li, M., Shepard, R. M., Patel, K., Koga, T., Sarver, A., Furnari, F., Xu, B., Dhawan, S., Ning, J., Zhu, H., Wu, A., You, G., Jiang, T., Venteicher, A. S., Rich, J. N., Glass, C. K., … Chen, C. C. (2021). PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response. Proceedings of the National Academy of Sciences, 118(16). https://doi.org/10.1073/pnas.2009290118 Cite
