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Pulmonary Cell NewsREsearchers developed a previously unidentified index, the T cell receptor (TCR)-based immunotherapy response index (TIR index), that estimated the degree of overlap of the TCR repertoire between tumor-infiltrating lymphocytes and circulating PD-1+CD8+T cells
[Science Advances]
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Han, J., Yu, R., Duan, J., Li, J., Zhao, W., Feng, G., Bai, H., Wang, Y., Zhang, X., Wan, R., Xu, J., Wang, X., Guan, Y., Xia, X., Yao, Z., Fei, K., Carbone, D. P., Wang, Z., & Wang, J. (2021). Weighting tumor-specific TCR repertoires as a classifier to stratify the immunotherapy delivery in non–small cell lung cancers. Science Advances, 7(21), eabd6971. https://doi.org/10.1126/sciadv.abd6971 Cite
