Hemocompatible L-Type Amino Acid Transporter 1 (LAT1)-Utilizing Prodrugs of Perforin Inhibitors Can Accumulate into the Pancreas and Alleviate Inflammation-Induced Apoptosis

The effects of prodrug 1 were studied in lipopolysaccharide-induced in vitro and in vivo apoptosis and pancreatitis models by determining the cellular apoptotic levels with human umbilical vein endothelial cells and pancreatic caspase-3/-7 activity in mice.