Scientists investigated the single-cell phenotypes associated with antimicrobial responses in human leprosy granulomas by applying single-cell and spatial sequencing to leprosy biopsy specimens.
[Nature Immunology]
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Ma, F., Hughes, T. K., Teles, R. M. B., Andrade, P. R., de Andrade Silva, B. J., Plazyo, O., Tsoi, L. C., Do, T., Wadsworth, M. H., Oulee, A., Ochoa, M. T., Sarno, E. N., Luisa Iruela-Arispe, M., Klechevsky, E., Bryson, B., Shalek, A. K., Bloom, B. R., Gudjonsson, J. E., Pellegrini, M., & Modlin, R. L. (2021). The cellular architecture of the antimicrobial response network in human leprosy granulomas. Nature Immunology, 1–12. https://doi.org/10.1038/s41590-021-00956-8 Cite