High Yap and Mll1 Promote a Persistent Regenerative Cell State Induced by Notch Signaling and Loss of p53

Using intestinal organoids, researchers showed that concomitant activation of Notch signaling and ablation of p53 induce a highly proliferative and regenerative cell state, which was associated with increased levels of Yap and the histone methyltransferase Mll1.