αSMA+ Fibroblasts Suppress Lgr5+ Cancer Stem Cells and Restrain Colorectal Cancer Progression

By
Justin.choi
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0
77
Scientists demonstrated that αSMA+ cancer-associated fibroblast in colorectal cancer (CRC) exert tumor-restraining functions via BMP4/TGFβ1 paracrine signaling that served to suppress Lgr5+ CSCs and promoted anti-tumor immunity, ultimately limiting CRC progression.
[Oncogene]

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Abstract