Identification of Cross-Reactive CD8⁺ T Cell Receptors with High Functional Avidity to a SARS-CoV-2 Immunodominant Epitope and Its Natural Mutant Variants

With a predicted peptide library from SARS-CoV-2 S and N proteins, restricted to three of the most prominent HLA-A alleles in the Asian population, investigators found that specific CD8+ T cell responses were identified in over 75% of COVID-19 convalescent patients